Life expectancy of people with HIV on long-term antiretroviral therapy in Europe and North America: a cohort study
نویسندگان
چکیده
BackgroundThe life expectancy of people with HIV starting combination antiretroviral therapy (ART) has increased substantially over the past 25 years. However, individuals treated before 1996 or less effective and more toxic regimens than those currently available might have a worse prognosis. We estimated from 2015 onwards, comparing who started ART in different time periods since 1996.MethodsData were derived 20 European North American cohorts (Antiretroviral Therapy Cohort Collaboration UK Collaborative Study), for potent after still on 2015, survived at least 1 year. Follow-up Jan 1, 2015. Associations between mortality demographic characteristics biomarkers (CD4 CD8 count cells per μL HIV-1 RNA viral load) follow-up start using multivariable Poisson models. Estimated rates 5-year age bands entered into tables that contain information to estimate expected remaining expectancy, stratified by sex variables associated mortality, standardised proportion each stratum. Life was compared French general population, as data France other countries included analyses.FindingsOf 206 891 eligible inclusion cohort data, 5780 died during 619 356 person-years For women, years 40 2014 36·0 (95% CI 35·4–36·6), whereas it 39·4 (39·0–39·8) (general population comparator 46·0 years). Corresponding figures men 34·7 (34·1–35·3) 37·2 (36·6–38·8), respectively 40·3 women 2014, CD4 0–49 commencement follow-up, 19·4 18·2–20·6), rising 40·4 (40·0–40·8) 500 greater follow-up. 24·9 (23·9–25·9) 42·6 (422–43·0), respectively. 18·2 (17·0–19·4), 38·2 (37·6–38·8) 23·7 (22·7–24·7) 39·5 (38·9–40·1), respectively.InterpretationFor long-term high cell counts, expectancies are be close regardless when they ART. low estimates up 30 lower indicating importance early diagnosis sustained treatment.FundingUS National Institute Alcohol Abuse Alcoholism, Medical Research Council.
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ژورنال
عنوان ژورنال: The Lancet Healthy Longevity
سال: 2022
ISSN: ['2666-7568']
DOI: https://doi.org/10.1016/s2666-7568(22)00063-0